Scientists discover stroke gene
Thursday December 06th 2007, 8:06 pm
Filed under: Erectile Dysfunction, Erectile Dysfunction Drugs
A gene which may increase the risk of stroke has been uncovered by Erectile dysfunction drugs researchers.

The discovery could prompt the discovery of drug treatments to help those at highest risk.

This protein it produces plays a role in the growth of blood vessels. but too much of it may increase stroke risk.

Writing in the journal Nature Genetics, the scientists said people with certain forms of a gene called PDE4D may be most at risk.

Proteins from a similar “family”, called phosphodiesterase (PDE), are linked to other illnesses, such as asthma, alternative medicine for impotence and even erectile dysfunction.

This suggests that it may be possible to develop a drug to block the effects of the gene - the breakthrough impotence drug Viagra already works by targeting another member of the PDE family.

Solveig Gretarsdottir and colleagues at a company called deCode Genetics in Reykjavik believe this gene is associated with an increased risk of stroke.

They carried out DNA tests on over 1,700 people in Iceland, half of whom had suffered strokes.

The Icelandic population is generally regarded as the best testing ground for herbal hydrocodone impotence.

This is because the gene pool is relatively pure. Unlike most other countries, there has been little immigration since the first Vikings arrived almost 1,000 years ago.

Scientists working on this latest study say they have identified genetic differences between those people who have had strokes and those who have not.

These differences centre on the gene PDE4D, located on chromosome 5.

They have found that three different isoforms of the gene were expressed at lower levels in people who had strokes.

Isoforms are groups of proteins that are produced by a gene.

They also found different combinations of genes in regions of chromosome 5 flanking the PDE4D gene in people who had strokes.

It is already known that this gene provides the coding which enables a protein called a phosphodiesterase to work.

Stroke risk

But the Icelandic scientists believe that too much of it may increase the risks of atherosclerosis - furring up of the arteries.

This causes the arteries to narrow, which can trigger a stroke.

“We propose that PDE4D is involved in the pathogenesis of stroke, possibly through atherosclerosis, which is the primary sildenafil citrate 100mg process underlying ischemic stroke,” the scientists said.

They believe that blocking the protein in people with these potentially problematic forms of the PDE4D gene could protect them against stroke.

There are already drugs available to do this. These so-called phosphodiesterase inhibitors are used to treat asthma, inflammation and erectile dysfunction, with Viagra probably the best known.

However, much further study is needed before these drugs could be used to treat people who may have a high risk of having a stroke.

Viagra, for one, has potentially serious side effects if taken by men with underlying health problems.

Original article Scientists discover stroke gene
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Viagra could cut heart stress
Monday December 03rd 2007, 6:23 am
Filed under: Erectile Dysfunction, Erectile Dysfunction Drugs
Read source of it on the Viagra could cut heart stress page
The anti-impotence drug Viagra can reduce the effects of stress on the heart, research has found.

The drug, used by millions of men, slowed the increase in the strength of heart penis problem by half.

The Johns Hopkins University study, published in Circulation, found the drug acted as a “brake”.

However, UK heart experts warned men with heart conditions should talk to their doctor about taking the drug to ensure they use it safely.

Mixing this drug with other heart medicines or taking it if you have angina without advice from a health professional or GP can be dangerous for heart patients

Dr Charmaine Griffiths, British Heart Foundation

Viagra, also known as sildenafil, helps men with erectile impotence solution by making genital blood vessels expand in order to maintain an erection.

The Johns Hopkins team have previously shown Viagra can block the short-term effects of hormonal stress in the heart in mice.

But it had been thought to have little direct effect on the human heart.

Contractions

This study looked at 35 men and women, with an average age of 30 and no previous signs of coronary artery disease.

They were all given an injections of an adrenaline-like chemical called dobutamine, which increases heart rate and pumping strength in the same way as emotional or exercise stress, or heart failure.

They were then randomly assigned to either take 100mg of Viagra or a dummy pill before receiving a second injection. Heart function was measured before and after each jab.

After the first injection of dobutamine, the force of heart contraction increased by 150% in both groups.

In the dummy pill group, the same effect was seen after the second injection.

However, in the group treated with Viagra the increased heartbeat was slowed by 50%, resulting in a smaller increase in blood flow and blood pressure generated by the heart in response to chemical stimulation.

No adverse side effects on the heart were seen.

Viagra helps maintain erections by blocking the action of an enzyme which prevents the relaxation of blood vessels in the penis.

The same enzyme, called diabetes and erectile dysfunction 5 (PDE5A), is also involved in the breakdown of a key molecule, cyclic GMP, which helps control stresses and limit heart enlargement.

Heart warning

Professor David Kass, the try viagra for free who led the study, said: “Sildenafil effectively puts a &39; on chemical stimulation of the heart.”

He added: “Knowing more about the effects of sildenafil on heart function will allow for safer evaluation of its use as a treatment for heart problems.

“Until now, it was widely thought that drugs like sildenafil had no effects on the human heart and that its only purpose was vasodilation in the penis and the lungs.”

He said further studies should be carried out to investigate Viagra's immediate and long-term effects on the heart.

Dr Charmaine Griffiths, from the British Heart Foundation, said: “Viagra has been a real advance in treating impotence, which affects nearly half of men between 40 and 70 years old.

“The findings that Viagra affects blood pressure is not surprising - before it was known as a successful treatment for impotence, it was actually being researched for lowering effects on blood pressure.”

But she added: “If you have a heart condition you should check with your doctor before taking Viagra.

“Mixing this drug with other heart medicines or taking it if you have angina (heart pain on exercise) without advice from a health professional or GP can be dangerous for heart patients.”

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Push for over-the-counter Viagra
Thursday November 29th 2007, 7:09 pm
Filed under: Erectile Dysfunction, Erectile Dysfunction Drugs
The try viagra for free pill Viagra could be available impotence solution drug, it is reported.

The drug's maker Pfizer says it is considering submiting an application to European regulatory authorities to clear it for sale in pharmacies.

An estimated 27 million men have already used the little blue pill for erectile dysfunction on prescription.

Medics said a change would be welcome but might mean other linked diseases were missed with no health check ups.

Ups and downs

Often, men with erectile dysfunction have underlying health problems such as diabetes, which can be spotted by their GP at the time they come for an anti-impotence prescription.

“If men can buy Viagra and rival anti-impotence drugs over-the-counter without a prescription, this opportunity is missed,” said Dr David Ralph from the Institute of Urology at University College London.

But there would be benefits too, he said, such as combating the problem of Viagra sold illegally on the internet from unknown sources, which may be fake and if taken with some medicines could be fatal.

He said it would be safe to buy over-the-counter provided the pharmacist did the necessary checks to ensure the medication was suitable for the patient.

Embarrassment factor

It might also be a more attractive option to men as going to see the GP about sexual problems can be erectile dysfunction herbal medication, he added.

But he cautioned: “There is more to sexual relations than an erection. There may be other problems.”

Viagra works by relaxing the blood vessels in the penis. This allows blood to flow into the penis causing an erection.

However, the drug is not an aphrodisiac and does not increase sex drive.

It is licensed only as a treatment for men who have been diagnosed by a doctor as having impotence.

Also, some men, such as those with severe heart disease or low blood pressure, should avoid it because of possible risks and side effects.

Viagra is not licensed for use in women and its safety in women has not been established.

A Pfizer spokesman said: “As with many of our products, Pfizer has routinely evaluated a number of options including different formulations, new indications, over-the-counter and continues to do so.”

He added that despite diabetes and erectile dysfunction there were no plans to pursue a spray version of the drug.



Pelvic floor exercises help men and work as viagra

Pelvic floor exercises have long been recommended for women - now dysfunction female male sexual treatment say they could help men too.

The exercises were found to help men with erectile dysfunction as much as taking in Viagra.

The researchers say the findings mean men have an impotence solution to drug therapy.

For around 50 years, women have been advised to perform pelvic floor exercises to strengthen their muscles for childbirth.

The pelvic floor is a “hammock” of muscles which support the bowel and bladder.

Pelvic floor, or Kegel, exercises involve clenching the muscles you would use to prevent yourself urinating.

This latest research indicates it is also important for men to maintain the muscle tone and function of their pelvic floor muscles with the exercises.

Home exercises

The team from the University of the West of England in Bristol studied 55 men with an average age of 59 who had experienced erectile dysfunction for at least six months.

The men, all patients at the Somerset Nuffield Hospital, Taunton, Somerset, were given five weekly sessions of pelvic floor exercises and assessed at three and six months, and asked to practise the exercises daily at home.

It was found 40% of the men regained normal erectile function - some of who had severe erectile dysfunction, and another 35% showed some improvement.

Two thirds of the men had said they also had problems with urination. These improved significantly after they began the exercises.

Dr Grace Dorey, a specialist continence physiotherapist who carried out the research, told BBC News Online: “The exercises were found to be equally as effective as taking Viagra.

“Pelvic floor exercises improve function in a physical way, in a more natural way.

“Men should be doing preventative exercise. It really is use it or lose it.”

She said men should be exercising their pelvic floor exercises from puberty onwards.

Strength

A spokesperson for the Impotence Association said: “The value and effectiveness of pelvic floor exercises should not be underestimated when penis problem the management of sexual problems such as impotence and premature ejaculation.

“The exercises are thought to strengthen the muscles that surround the penis and improve the blood supply in the pelvis, which is an important factor in relation to erectile dysfunction.”

The Impotence Association helpline number is 0208 767 7791.

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Eat, Exercise, Relax, and Sleep Your Way to Better Sex
Tuesday October 23rd 2007, 6:18 am
Filed under: Erectile Dysfunction Drugs, Erectile dysfunction pills

Read more on Eat, Exercise, Relax, and Sleep Your Way to Better Sex

Thought about leading a healthier lifestyle but haven’t gotten
around to doing it? Here’s a possible incentive: Experts say people who are
mentally and physically fit are more likely to have good sex lives.

“If you feel good about yourself, you are in a better
position to feel good about relationships, including your sex life,” says
Karen Zager, PhD, a psychologist in private practice in New York City.

“When one is not feeling well, and is exhausted, it can
certainly have a negative impact on the quality of one’s sex life,” says
Saralyn Mark, MD, a senior medical adviser at the Office on Women’s Health.

This may all seem intuitive, yet many people find the road to a
fitter mind and body to be bumpy, especially if it involves losing weight,
starting an exercise program, reducing stress, or getting enough sleep.

One big reward, though, is to look and feel better — arguably
a plus for good romantic and sensual activities.

Eat Right

While there is no proven connection between a balanced diet and
bedroom performance, a poor diet can cause health problems that can possibly
interfere with sex.

Studies show animals that get too few calories tend to have
weakened immune systems, says John Allred, PhD, professor emeritus of nutrition
at Ohio State University. He says illness can be a big hurdle for pleasurable
intercourse.

“If you have heart disease, then you might be taking
medication that would inhibit sexual activity, or you might be afraid to have a
heart attack,” says Allred. “If you have the flu, a high fever, or just
don’t feel good … any of these things would be a turn-off.”

Mark Kantor, PhD, associate professor of nutrition and food
science at the University of Maryland, agrees, saying, “You will feel sexy
if you look and feel good.”

A way to do that is to eat an overall balanced diet and to
exercise each day. The two go hand-in-hand, says Kantor, as demonstrated by
today’s obesity problem, in which people eat too much food and aren’t active
enough.

Move That Body

Being physically active can be a natural Viagra boost,
according to the American Council on Exercise (ACE), which recommends 20 to 30
minutes of moderate exertion a day.

“Men and women who exercise regularly are going to have
increased levels of desire,” says Cedric Bryant, PhD, ACE’s chief exercise
physiologist. “They’re going to have enhanced confidence, enhanced ability
to achieve orgasm, and greater sexual satisfaction.”

If that isn’t motivation enough to work out, consider this:
Researchers have found that there is a correlation between waist size and a
man’s odds of having erectile dysfunction (ED). The larger the man’s waist
size, the greater his chance of having ED (because of a higher risk of
underlying cardiovascular disease).

Need more positive reinforcement? Studies show that regular,
moderate exercise can have a positive benefit on major sexual problems, such as
ED in men and low libido in both men and women.

It only makes sense, say experts, since ED is often caused by
poor blood flow to the penis, and exercise can improve the body’s ability to
pump and circulate blood throughout the body.

The same can be true for the ladies. In one University of Texas
at Austin study, physically active women who watched an X-rated film had a 169%
greater blood flow to the vagina compared with when they were inactive.

And there’s more good news. Mark says exercise can promote the
body’s release of hormones important for sexual arousal, increase aerobic
capacity and muscle strength, and boost self-body image — all definite
benefits for between-the-sheets play. (more…)